Antibiotic resistance is a very serious threat to human and animal health. It can only be tackled by an international coordination of all efforts as in the One Health Concept. Promoting responsible use and reducing the amount of antibiotics used in people, and animals worldwide is vital for maintaining the efficacy of the antibiotics to fight bacterial diseases in animals and humans. Animals that are well cared for and appropriately housed, will experience a better welfare, be less prone to infections and will need fewer antibiotics. The European veterinary profession, having a key role in animal health, welfare, food safety, environmental protection and sustainable keeping of animals is committed to take leadership in fighting antimicrobial resistance.